Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 918504-27-5, name is N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
General procedure: Aryl bromide (1 eq.), K2C03(2 eq.) and boronic acid / pinacol ester (1.2 eq.) were suspended in DME/H20 (0.15 m, 4:1 ) and degassed with argon for 10 min. Pd(PPh3)4(0.05 eq.) was added and the suspension, which was then irradiated at 130C for 30 min ^w). The resulting mixture was passed through a Celite pad and the solvent was removed under reduced pressure. The crude mixture was purified via flash chromatography (Si02, DCM/MeOH (content of MeOH increased in 0.5%-steps from 0 to 5% (v/v)) to yield the titled compound.
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Reference:
Patent; HEPAREGENIX GMBH; ALBRECHT, Wolfgang; LAUFER, Stefan; SELIG, Roland; KLOeVEKORN, Phillip; PRAeFKE, Bent; (121 pag.)WO2018/134254; (2018); A1;,
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