Reference of 62089-74-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62089-74-1, name is 1-(Pyridin-4-ylmethyl)piperazine, molecular formula is C10H15N3, molecular weight is 177.25, as common compound, the synthetic route is as follows.
Example 200 {4-Chloro-3-[2-(2,4-Dichloro-Phenyl)-Ethoxy]-5-Methoxy-Phenyl}-(4-Pyridin-4-Ylmethyl-Piperazin-1-Yl)-Methanone 0.050 g (0.13 mmol) of 4-Chloro-3-[2-(2,4-dichloro-phenyl)-ethoxy]-5-methoxy-benzoic acid was dissolved in 3 ml of DMF and treated with 0.061 g (0.53 mmol) of NEM and 0.043 g (0.13 mmol) of TOTU and 0.024 g (0.13 mmol) of 1-Pyridin-4-ylmethyl-piperazine. The solution was stirred for 16 h at RT. The solvent was removed under reduced pressure. The residue was purified by preparative RP-HPLC eluding with a gradient of 0 to 100% acetonitrile in water (+0.01% trifluoroacetic acid). After lyophilization the product was obtained as its trifluoroacetate salt.
Statistics shows that 62089-74-1 is playing an increasingly important role. we look forward to future research findings about 1-(Pyridin-4-ylmethyl)piperazine.
Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem