Related Products of 779345-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 779345-37-8, name is 5-Fluoro-2-nitropyridine. A new synthetic method of this compound is introduced below.
To a solution of compound 73 (564 mg, 4.2 mmol, 1.2 eq) in dimethylacetamide (5 mL) at 0 C under nitrogen was added potassium tert-butoxide (513 mg, 4.6 mmol, 1.3 eq) portion wise. The mixture was stirred at 0 C for 1 h, and then a solution of compound 61 (500 mg, 3.5 mmol, 1.0 eq) in DMA (2 mL) was added portion wise. After addition, the reaction mixture was stirred at RT overnight. The reaction was quenched by water (15 mL) and extracted with EA (3 X 5 mL), dried over Na2S04, filtered and concentrated to give a crude residue (700 mg crude), which was used into next step without further purification. *H NMR (300 MHz, CDCb): delta 8.34-8.31 (m, 2 H), 7.72 (dd, J = 3.0 Hz, 9.0 Hz, 1 H), 4.07 (d, J = 6.0 Hz 2 H), 2.80- 2.76 (m, 2 H), 2.15 (s, 3 H), 1.89-1.81 (m, 2 H), 1.75-1.71 (m, 2 H), 1.37-1.23 (m, 3 H). LCMS: (M+H)+ = 252.2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,779345-37-8, its application will become more common.
Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem