With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.153034-86-7, name is 2-Chloro-4-iodopyridine, molecular formula is C5H3ClIN, molecular weight is 239.44, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Chloro-4-iodopyridine
Method 2: Sonogashira route B Step 1 : 2-Chloro-4-phenylethvnyl-pyridine To the degassed mixture of triethylamine (375ml_) and acetonitrile (125ml_) was added 2-Chloro 4-iodopyridine (75g, 0.313mol), bis(triphenylphosphine) palladium(ll)chloride (4.4g, 2mol%) and copper iodide (0.6g, 1 mol%) sequentially. The mixture was stirred at room temperature for 3h. Phenylacetylene dissolved in acetonitrile(250 ml_) was then added dropwise to reaction mixture and it was stirred for 1 hr at room temperature. Reaction was monitored by TLC. Acetonitrile and triethylamine was removed under vacuo, and the residue was purified by column chromatography using silica with mixture of ethyl acetate and hexane solvent system to yield product (59g, 88%).1 H NMR (CDCIa): delta 8.36( d, J = 5.2 Hz, 1 H), 7.53-7.55 (m, 2H), 7.43( s, 1 H), 7.39- 7.42(m, 3H), 7.29(dd, J = 5.4 Hz, 1.2 Hz, 2H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,153034-86-7, 2-Chloro-4-iodopyridine, and friends who are interested can also refer to it.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; CEDERBAUM, Fredrik; UMARYE, Jayant; DUMEUNIER, Raphael; SONAWANE, Ravindra; WO2012/84678; (2012); A1;,
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