Reference of 74784-70-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, molecular weight is 162.1125, as common compound, the synthetic route is as follows.
EXAMPLE 13-(4-Methylsulfonyl)phenyl-2-pyrrolidin-1-yl-5-trifluoromethylpyridineStep 1: 2-Amino-3-bromo-5-trifluoromethylpyridine To a solution of 2-amino-5-trifluoromethylpyridine (9 g) in acetic acid (75 mL) at r.t. was added bromine (5.8 mL) slowly. After 1 h, the acid was neutralized by the careful addition of sodium hydroxide (10 N) at 0C. The resulting orange precipitate was dissolved in ether and washed successively with saturated potassium carbonate, saturated Na2SO3 and brine, dried and concentrated. The residual solid was stirred vigorously in hexane for 1 h to provide, after filtration, the title compound as a white solid (10.2 g).
Statistics shows that 74784-70-6 is playing an increasingly important role. we look forward to future research findings about 5-(Trifluoromethyl)pyridin-2-amine.
Reference:
Patent; MERCK FROSST CANADA & CO.; EP1015431; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem