Adding a certain compound to certain chemical reactions, such as: 15855-06-8, 2-Chloro-6-methoxypyridine-4-carboxylic Acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 15855-06-8, blongs to pyridine-derivatives compound. SDS of cas: 15855-06-8
Example 4.2: (S)-2-chloro-6-methoxy-N-methyl-N-(4-M-methyl-1 H-pyrrole-2- carboxamido)-1-phenylbutan-2-yl)isonicotinamide1-Methyl-1 H-pyrrole-2-carboxylic acid ((S)-3-methylamino-4-phenyl-butyl)-amide hydrochloride (100 mg, 0.31 mmol), 2-chloro-6-methoxyisonicotinic acid (58 mg, 0.31 mmol), HOBt (74 mg, 0.466 mmol), EDC x HCI (72 mg, 0.37 mmol), and triethylamine (0.108 ml, 0.78 mmol) were dissolved in DCM (3 ml) and stirred at rt for 16 h. The mixture was concentrated and the crude product was purified by chromatography (Flashmaster, DCM to DCM:EtOAc 1 :1 over 15 min) to yield 108 mg (76 %) of the title compound as white solid. [1 H-NMR (DMSO, 600 MHz) 7.95-7.90 (m, 1 H), 7.33.7.22, 7.10-7.06 (2m, 5H), 6.87 (d, 1 H), 6.70/6.63 (d, 1H), 6.65/6.33 (s, 1 H), 6.06/5.71 (br.s, 1H), 6.00-5.97 (m, 1 H), 4.88-4.81/3.55-3.49 (m, 1H), 3.84/3.71 (s, 3H), 3.80/3.79 (s, 3H), 3.27-3.18/3.05-2.99 (m, 2H), 2.97/2.62 (s, 3H), 2.95-2.90/2.84-2.76 (m, 2H), 1.91-1.75 (m, 2H); LCMS Rtc = 2.466 min; [M+H]+ = 455.2].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15855-06-8, 2-Chloro-6-methoxypyridine-4-carboxylic Acid, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; WAGNER, Juergen; ROY, Bernard, Lucien; GERSPACHER, Marc; VON MATT, Anette; BEHNKE, Dirk; WO2011/73316; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem