New learning discoveries about tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,119285-07-3, its application will become more common.

Reference of 119285-07-3 ,Some common heterocyclic compound, 119285-07-3, molecular formula is C14H22N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(5-Bromo-2-chloro-pyrimidin-4-yl) -cyclopentyl-amine (0.155 g, 0.560 mmol) and 4- (5-amino-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester (0.156 g9 0.560 mmol) were dissolved in toluene and heated to 115C for 48H. The reaction was cooled and concentrated. Purification on silica gel using 4: 1 HEXANE/ETOAC PROVIDED 0. 130 g (45%) OF 4- [5- (5-BROMO-4-CYCLOPENTYLAMINO- PYRIMIDIN-2-YLAMINO)-PYNIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC acid tert-butyl ester.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,119285-07-3, its application will become more common.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/65378; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem