Reference of 17228-64-7 ,Some common heterocyclic compound, 17228-64-7, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Under Nitrogen, to a 10 mL Schlenk flask equipped with a magnetic bar, potassium hydroxide (4.5 mmol, 252 mg), phenyl boronic acid (3.15 mmol), and aryl chlorides (3 mmol) (if liquid, was injected through the septum later), catalyst 3 (0.05 mol% catalyst loading, 1 mg) were added in turn, followed by addition of 2-propanol (5 mL) and H2O (0.5 mL). The mixture was then stirred at 80 for 2 h. It was also monitored by gas chromatography. Water was added to the reaction mixture, which was extracted by ethyl acetate, dried over anhydrous Na2SO4, and the solvent was evaporated in vacuum. When necessary the product was purified by flash chromatography.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17228-64-7, 2-Chloro-6-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Shen, An; Hu, Yu-Cai; Liu, Ting-Ting; Ni, Chen; Luo, Yong; Cao, Yu-Cai; Tetrahedron Letters; vol. 57; 19; (2016); p. 2055 – 2058;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem