Electric Literature of 128071-98-7, Adding some certain compound to certain chemical reactions, such as: 128071-98-7, name is 4-Bromo-2-fluoropyridine,molecular formula is C5H3BrFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 128071-98-7.
Step 1: Preparation ofl-(4-bromopyridin-2-yl)cyclopropanecarbonitrile.LiHIVIDS (1 M in toluene, 17.6 mL, 17.6 mmol, 3.1 eq) was added dropwise to a cold (-5C) mixture of 4-bromo- 2-fluoropyridine (1 g, 5.7 mmol), cyclopanecarbonitrile (1.25 mL, 17 mmol, 3 eq) and4A MS in toluene (20 mL). The reaction mixture was allowed to warm to room temperature and stirred for 16 hr. After it was poured into water, the mixture was filtered. The filtrate was diluted with EtOAc and 1120, and extracted with EtOAc. The organic phase was washed with water and brine, dried over anhydrous Na2504, and concentrated. The residue was purified by column chromatography using PE/EtOAc (9:1) as eluent to give the desired product. LC-MS: m/z 223.0 (M+H).
According to the analysis of related databases, 128071-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; ZAHLER, Robert; CAI, Zhenwei; ZHOU, Ding; WO2015/3640; (2015); A1;,
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