Reference of 14254-57-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14254-57-0, name is Isonicotinoyl chloride, molecular formula is C6H4ClNO, molecular weight is 141.5551, as common compound, the synthetic route is as follows.
To a suspension of indigo (1.0 g, 3.8 mmol) in anhydrous ethyl acetate (50m1) containing sodium acetate (0.8 g, 9.5mmol) and zinc (2.49 g, 38 mmol) was added isonicotinoyl chloride (2.0 g, 11.4 mmol). The reaction mixture was allowed to stir for 30 mins at 40C. The suspension was allowed to cool to room temperature and then concentrated to dryness. The residue was extracted with hot acetone. The crude material was purified using flash column chromatography eluting with 20% ethyl acetate: pet ether. The product was isolated as a pale yellow solid and was confirmed by ?H NMR to be the di-substituted product, Compound 22(0.4g, 22%). Mw, C28H18N404, 474.47; ?H NMR (400 MHz, DMSO) oe 11.36 (s, 1H), 11.12 (s, 1H),7.59 (d, J 8.0 Hz, 1H), 7.50 (dd, J 8.1, 0.9 Hz, 1H), 7.46 – 7.41 (d, 8.1 Hz, 1H), 7.36 (d, J=8.1 Hz, 1H), 7.16 (dddd, J= 12.9, 8.2, 7.0, 1.2 Hz, 2H), 7.05 (ddt, J 8.1, 7.0, 1.1 Hz, 2H), 6.84(dd,J= 2.1, 0.8 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 14254-57-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; VF JEANSWEAR LP; PUVVADA, Sudhakar; SCHEER, Dennis; HOERTZ, Paul, Gerard; (146 pag.)WO2019/126469; (2019); A1;,
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