The synthetic route of 849067-96-5 has been constantly updated, and we look forward to future research findings.
In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 849067-96-5, name is Methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate, the common compound, a new synthetic route is introduced below. Quality Control of Methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate
Preparation of methyl 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (G-1 -2)G-1 -1a G-1 -2 To a solution of G-1-1a (58 g, 0.33 mol) in dry THF (800 mL) was added NaH (20 g, 0.495 mol) at 0-100C in small portions. The resulting mixture was stirred at 1O0C for 1 h. BsCI (70.1 g, 0.397 mol) was added drop-wise. The resulting mixture was allowed to warm to room temperature and stirred overnight. TLC (Petroleum ether: EtOAc = 2:1 ) indicated the reaction was complete. The reaction mixture was cooled and quenched with water. The mixture was extracted with EtOAc (400 mLchi3). The combined organic layers were washed with saturated aqueous NaCI, dried with Na2SO4, filtered and concentrated to give crude product, which was purified by re-crystallization with petroleum ether: EtOAc =3:1 to give compound G-1-2 (60 g , 57.6%) as a grey yellow solid.
The synthetic route of 849067-96-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; WO2009/16460; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem