Reference of 59782-85-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59782-85-3, name is 2,5-Dichloronicotinic acid, molecular formula is C6H3Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2,5-dichloronicotinic acid (30 g, 0.16 mol) in toluene (100 ml) was added ethanol (50 ml) and conc. sulfuric acid (1 ml). The reaction mixture was heated at 130 C for 3 days with stirring. Then the reaction mixture was cooled and poured into sat. sodium bicarbonate solution. The whole mixture was extracted with ethyl acetate. The organic phase was washed with brine, dried (sodium sulfate), and concentrated to afford 34 g (quant. ) of title compound: ‘H-NMR (CDCI3) 8 8.48 (1 H, d, J = 2.6 Hz), 8.15 (1 H, d, J = 2.6 Hz), 4.44 (2H, dd, J = 7.1, 14.3 Hz), 1.42 (3H, t, J = 7.1 Hz).
According to the analysis of related databases, 59782-85-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/102389; (2005); A2;,
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