Electric Literature of 31872-63-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31872-63-6, name is 3-Bromo-4-chloro-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
3-bromo-4-methyl-5-nitropyridine (94a) Diethyl malonate (3.84 mL, 25.3 mmol) was slowly added to a suspension of sodium hydride (1.01 g of a 60% suspension in oil, 25.3 mmol) in DMF (15 mL) at 0 C. and stirred 30 min until gas evolution ceased. 3-bromo-4-chloro-5-nitropyridine (3.00 g, 12.6 mmol) was added slowly, and the dark reddish-brown solution was stirred at room temperature for 1 hour. The reaction was carefully quenched with water and acidified to pH 1 with 1N HCl. The aqueous mixture was extracted with EtOAc (2*150 mL). The combined organics were washed with water (100 mL) and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The residue was diluted with 4N HCl (50 mL) and the solution refluxed 16 hours. The mixture was cooled in an ice bath and basified to pH 7 with 50% NaOH. The aqueous mixture was extracted with EtOAc (3*100 mL) and the combined organics were washed with brine, dried (MgSO4), filtered and concentrated in vacuo to afford 94a (1.90 g, 70%) as a yellow solid. 1H NMR (300 MHz, CDCl3) delta 8.94 (s,1H), 8.97 (s,1H), 2.65 (s, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 31872-63-6, 3-Bromo-4-chloro-5-nitropyridine.
Reference:
Patent; PFIZER INC; US2005/90529; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem