Electric Literature of 100-26-5 ,Some common heterocyclic compound, 100-26-5, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
PREPARATION 1 dimethyl Pyridine-2,5-dicarboxylate To a stirred slurry of 2,5-pyridinedicarboxylic acid (2407 g; 14.4 mol) in methanol (8.0 liter) at -5 to -10C, thionylchloride (3430 g; 2.10 liters; 28.8 mol) was added dropwise while maintaining the temperature in the -5 to -10C range. After completing the addition, the reaction was allowed to warm to ambient temperature, and stirred for 18 hours. The resulting solution was concentrated in vacuo to a volume of 4 liters, and an equal volume of water was added. The PH of the well-stirred mixture was then adjusted to 10 with saturated aqueous sodium carbonate. Solids were removed by filtration. The organic layer of the filtrate was separated, washed with water (8 liters), and dried in vacuo to afford the title compound (2250 g; 80% yield) as an amorphous solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-26-5, 2,5-Pyridinedicarboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; EP536173; (1995); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem