Reference of 86447-11-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 86447-11-2, name is 1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below.
22.7 g of N-Boc-1,2,3,6-tetrahydropyridine-5-carboxylic acid (0.1 mol) and 120 mL of toluene were added to a 250 mL reaction flask, and 16.6 g (0.1 mol) of bromine was added dropwise at room temperature. After the completion of the addition, the reaction was stirred at room temperature for 30 minutes. After completion of the TLC reaction, 20 mL of sulfolane was added, the temperature was raised to 50-60 C, and 31.2 g (0.4 mol) of pyridine was added dropwise. After the dropwise addition, the bubble is no longer escaped, the temperature to 80-90 reaction 2-3 hours, vacuum distillation 18.1g of colorless liquid N-Boc-1, 2,3,6-tetrahydropyridine-5-bromide in 69% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,86447-11-2, 1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Cangzhou Puri Oriental Technology Co., Ltd; Leng, Yanguo; Yu, Weidong; Zhang, Jin; (6 pag.)CN105503924; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem