Application of 6345-27-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6345-27-3, name is Isonicotinimidamide hydrochloride. A new synthetic method of this compound is introduced below.
2. 2-(4-Pyridinyl)-4-pyrimidinamine – A mixture containing 5.4 g. of sodium methoxide, 50 ml. of methanol and 31.6 g. of isonicotinamidine hydrochloride was stirred for thirty minutes and stripped to dryness to remove the solid. To the residue was added 250 ml. of tetrahydrofuran and the resulting slurry was stirred in an ice bath. To the stirred mixture was added dropwise over a period of thirty minutes 18 g. of alpha-chloroacrylonitrile. After the reaction mixture had been stirred for an additional two hours, it was allowed to stand at room temperature for one hour and then refluxed for four hours. To the reaction mixture was added 15 ml. of 35percent aqueous sodium hydroxide solution and the mixture chilled. The solid was collected, washed with water and dried to yield 21.1 g. of 2-(4-pyridinyl)-4-pyrimidinamine, m.p. 264°-267° C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6345-27-3, its application will become more common.
Reference:
Patent; Sterling Drug Inc.; US4109092; (1978); A;,
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