Adding a certain compound to certain chemical reactions, such as: 16179-97-8, 2-(Pyridin-2-yl)acetic acid hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(Pyridin-2-yl)acetic acid hydrochloride, blongs to pyridine-derivatives compound. Quality Control of 2-(Pyridin-2-yl)acetic acid hydrochloride
To a suspension of 5-nitroindoline (3.28 g), 2- pyridylacetic acid hydrochloride (3.82 g), 1- [3- (dimethylamino) PROPYL]-3-ETHYLCARBODIIMIDE hydrochloride (4.22 g) and 1-hydroxybenzotriazole hydrate (3.37 g) in dichloromethane (100 ml) was added dropwise triethylamine (4.45 g) at ambient temperature and the resultant solution was stirred at ambient temperature for 18 hours. The mixture was poured into water and the separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with ethyl acetate to give 5-nitro-l- (2-pyridinylacetyl) indoline (3.58 g) as a yellow solid. 1H-NMR (DMSO-d6) : 8 3.26 (2H, t, J=8.5 Hz), 4.10 (2H, s), 4.33 (2H, t, J=8.5 Hz), 7.25-7. 35 (1H, m), 7.38 (1H, d, J=7.8 Hz), 7.75- 7.9 (1H, m), 8.1-8. 2 (3H, m), 8.50-8. 55 (1H, m) APCI-MS (m/z): 284 (M+H) +
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16179-97-8, 2-(Pyridin-2-yl)acetic acid hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; DAISO CO., LTD.; WO2004/39795; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem