Reference of 104830-06-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104830-06-0, name is 2-Amino-3-iodopyridine, molecular formula is C5H5IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A solution of the substituted 2-iodoaniline or 2-bromoaniline (1.0 equiv), DMAP (0.05 equiv) and NEt3 (2.0 equiv) was prepared in CH2Cl2 (2mL) and cooled to 0 C. The acyl chloride solution was added dropwise into the solution. After 5 minutes, the reaction was allowed to warm to room temperature and was stirred overnight. The reaction was quenched with a saturated NaHCO3 solution and extracted with CH2Cl2 twice. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo. The resulting crude amide was used in next step without further purification.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 104830-06-0, 2-Amino-3-iodopyridine.
Reference:
Article; Xiao, Genhua; Chen, Liang; Deng, Guobo; Liu, Jianbing; Liang, Yun; Tetrahedron Letters; vol. 59; 19; (2018); p. 1836 – 1840;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem