As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-05-1, name is 2,6-Dibromopyridine, molecular formula is C5H3Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 626-05-1
General procedure: Into a 25 mL round-bottomed flask were added Pd(PPh3)2Cl2 (0.06 g, 2.0 mol %), 2,6-dibromopyridine (0.60 g, 2.5 mmol) and 5.0 mL of 4-(ethoxycarbonyl)-phenylzinc bromide (0.5 M in THF, 2.5 mmol) under an argon atmosphere at room temperature. The resulting mixture was stirred at room temperature for 0.5 h. Quenched with saturated NH4Cl solution, then extracted with ethyl ether (10 mL × 3). Washed with saturated NaHCO3, Na2S2O3 solution and brine, then dried over anhydrous MgSO4. Purification by column chromatography on silica gel (10% ethyl acetate/90% heptane) afforded 0.31 g of 3a in 50% isolated yield as a white solid.
With the rapid development of chemical substances, we look forward to future research findings about 626-05-1.
Reference:
Article; Jung, Hye-Soo; Kim, Seung-Hoi; Bulletin of the Korean Chemical Society; vol. 35; 1; (2014); p. 280 – 282;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem