Related Products of 68470-59-7 , The common heterocyclic compound, 68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[2-chloro-5-[(E)-N-hydroxy-C-methyl-carbonim idoyl]phenyl]methyl N-methylcarbamate (500 mg, 1 .9 mmol) and 2-(bromomethyl)-6-methylpyridine (720 mg, 3.9 mmol) were dissolved in dimethyl formamide (DMF) (35 mL). Then K2C03 (810 mg, 5.8 mmol) was added and themixture was stirred at room temperature overnight. After the addition of water, the solution was extracted with EtOAc and the organic layer was dried over Na2SO4. Concentration and purification by preparative H PLC yielded in [2-chloro-5-[(E)-C-methyl-N-[(6-methyl-2- pyridyl)methoxy]carbonimidoyl]phenyl]methyl N-methylcarbamate (190 mg, 28%) as a pale white solid and in its Z-isomer (160 mg, 23%) as a white solid.
The synthetic route of 68470-59-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; WINTER, Christian; RHEINHEIMER, Joachim; WOLF, Antje; POONOTH, Manojkumar; TERTERYAN, Violeta; WIEBE, Christine; KREMZOW-GRAW, Doris; ROeHL, Franz; GRAMMENOS, Wassilios; ROHRER, Sebastian Georgios; WIEJA, Andy; ROSENBAUM, Claudia; WO2014/207071; (2014); A1;,
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