Synthetic Route of 86873-60-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86873-60-1, name is 5-Chloro-2-picolinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 5- chloropyridine-2-carboxylic acid (4g, 25.4 mmol) in acetonitrile (250 mL) were added DMAP (0.3g, 2.54 mmol) and TEA (5.3 mL, 38.1 mmol) at 0 C followed by a solution of B0C2O (8.3g, 38.1 mmol) in acetonitrile (50 mL). The resulting light brown solution was warmed up to room temperature and stirred overnight. The solvent was removed in vacuo to afford a white solid which was purified by column chromatography (4:1 Hexanes: EtOAc) to give a white solid (4.5g, 83% yield), mp 86.3-88.3 C. NMR (300 MHz, DMSO-cfo 5 8.75 (dd, J = 2 and 1 Hz, 1H), 8.1 1 (dd, J = 8 and 2 Hz, 1H), 8.00 (dd, J = 8 Hz, 1H), 1.55 (s, 9H).
According to the analysis of related databases, 86873-60-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HAMMOCK, Bruce, D.; HWANG, Sung, Hee; WECKSLER, Aaron, T.; MORISSEAU, Christophe; WO2012/112570; (2012); A1;,
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