Synthetic Route of 874959-68-9, Adding some certain compound to certain chemical reactions, such as: 874959-68-9, name is 5-Bromopyridine-2-sulfonyl chloride,molecular formula is C5H3BrClNO2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874959-68-9.
General procedure: To a pyridine (1.5 mL) solution of 5-((1S,2R)-1-amino-2-(6-fluoro-2,3-dimethylphenyl)propyl)-1,3,4-oxadiazol-2(3H)-one monohydrochloride (45 mg) obtained from Reference Example F1, 5-chloro-8-(chlorosulfonyl)-4-methyl-d3-chroman-4-ylacetate (80 mg) obtained in Reference Example E1 was added, and the reaction solution was stirred atroom temperature for 12 hours. The reaction solution was concentrated under reduced pressure, and the obtainedresidue was purified by silica gel column chromatography (eluent: hexane / ethyl acetate) to obtain the title compound(59 mg) as a 1: 1 diastereomer mixture.
According to the analysis of related databases, 874959-68-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Taiho Pharmaceutical Co., Ltd.; MIYAHARA, Seiji; UENO, Hiroyuki; HARA, Shoki; OGINO, Yoshio; (203 pag.)EP3466934; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem