Synthetic Route of 56622-54-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56622-54-9, name is (6-Methylpyridin-3-yl)methanamine, molecular formula is C7H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 5-(ethoxycarbonyl)-4′-methylbiphenyl-3-carboxylic acid (1.5 g, 5.3 mmol), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (2.0 g, 10 mmol), 1- hydroxybenzotriazole hydrate (0.32 g, 2.1 mmol), and CH2Cl2 (50 mL) were added (6-methylpyridin-3- yl)methanamine (0.97 g, 7.9 mmol) and NN-diisopropylethylamine (1.8 mL, 10 mmol). The mixture was stirred at room temperature for 4h, and then washed with water and aq. Na2CO3 solution, dried (Na2SO4), and concentrated in vacuo. The residue was purified by silica gel column to afford a white foam. LC-MS: 389.4 [M+l]+; 1H NMR (400 MHz, CDCl3): 8.53 (d, IH, J = 2.0 Hz), 8.39 (t, IH, J = 1.6 Hz), 8.29 (t, IH, J = 1.6 Hz), 8.26 (t, IH, J = 1.6 Hz), 7.66 (dd, IH, J = 8.0, 2.0 Hz), 7.55 (d, 2H, J = 8.4 Hz), 7.28 (d, 2H, J = 8.0 Hz), 7.17 (d, IH, J = 8.0 Hz), 6.64 (m, IH), 4.67 (d, 2H, J = 5.6 Hz), 4.42 (q, 2H, J = 7.2 Hz), 2.57 (s, 3H), 2.41 (s, 3H), 1.42 (t, 3H, J = 7.2 Hz).
According to the analysis of related databases, 56622-54-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem