Analyzing the synthesis route of 65-22-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65-22-5, its application will become more common.

Electric Literature of 65-22-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 65-22-5 as follows.

General procedure: The ligands L3, L4, L5 and L6 were synthesized using pyridoxal hydrochloride (0.180g, 8mmol) solubilized in methanol (15mL). Then 4-hydroxybenzoic hydrazide (L3), 4-methoxybenzoic hydrazide (L4), 4-aminobenzoic hydrazide (L5), and 4-nitrobenzoic hydrazide (L6) were added (0.134g, 0.146g, 0.133g, 0.160g, 8mmol each, respectively). The reaction solution remained at 50C and constant stirring, with reaction time of 2h (L3-L4) and 3h (L5-L6). After this period, the reaction mixture was cooled to room temperature and the methanol was then evaporated under reduced pressure, whereby a yellow solid was obtained (Scheme 2 ). Thin-layer chromatography plates monitored the reactions (Hex/Ac 80-20). The synthetic route used to obtain the L4 ligand is similar to that proposed by K. Ramdasand and co-workers [29].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65-22-5, its application will become more common.

Reference:
Article; Arantes, Leticia Priscilla; Back, Davi Fernando; Chaves, Otavio Augusto; Iglesias, Bernardo Almeida; Neves, Ademir; Piquini, Paulo Cesar; Siqueira, Josieli Demetrio; Soares, Felix Antunes; de Pellegrin, Sidnei Flores; dos Santos, Sailer Santos; Journal of Inorganic Biochemistry; vol. 204; (2020);,
Pyridine – Wikipedia,
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