With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-33-6, name is 3-Bromo-2-hydroxy-5-nitropyridine, molecular formula is C5H3BrN2O3, molecular weight is 218.99, as common compound, the synthetic route is as follows.SDS of cas: 15862-33-6
Under ice-cooling, to a solid mixture of 3-bromo-5-nitro-2-ol (21.4 mmol) and quinoline (10.7Mmol) was slowly added dropwise phosphorus oxychloride (27.8 mmol). The mixture was stirred at 120 C for 3.5 hours, cooled to to 100 C, was added 10 ml of water. The reaction was stirred vigorously in an ice water bath for 1 hour. The precipitate was collected by filtration, washed with water, and dried to give 4.15 g of the title compound. 1H-NMR (CD30D) S9.09 (lH, d, J = 2.4Hz), 8.40 (lH, d, J = 2.4Etazeta).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15862-33-6, 3-Bromo-2-hydroxy-5-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICALGROUP CO LTD; Beijing Centaurus Biopharma Technology Co., Ltd.; XIAO, DENGMING; LIANG, ZHI; HU, YUANDONG; HU, QUAN; ZHANG, QINGHUI; HAN, YONGXIN; WANG, HUAN; PENG, YONG; KONG, FANSHENG; LUO, HONG; (60 pag.)CN103130792; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem