Electric Literature of 6345-27-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, molecular weight is 157.6, as common compound, the synthetic route is as follows.
To a stirred solution of G-1 (2.5 g, 6.4 mmol) in ethanol (24 mL) was added, at room temperature isonicotinimidamide hydrochloride H-1 (1.5 g, 9.65 mmol) followed by potassium tert-butoxide (1.44 g, 12.9 mmol). [0112] The reaction mixture was then heated at 80° C. for 16 hours. After 100percent consumption of G-1 (monitoring by LCMS), the reaction mixture was allowed to cool to room temperature and concentrated in vacuum. The residue was, then, diluted with dichloromethane (150 mL) and treated with water (150 mL). The aqueous crude mixture was extracted with dichloromethane (2×150 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuum. The crude compound was then purified on silica gel using dichloromethane/ethyl acetate: 50/50 to afford the desired intermediate I-1 as a light white solid (2.58 g, 90percent yield).
Statistics shows that 6345-27-3 is playing an increasingly important role. we look forward to future research findings about Isonicotinimidamide hydrochloride.
Reference:
Patent; Bonfanti, Jean-Francois; Muller, Philippe; Doubler, Frederic Marc Maurice; Fortin, Jerome Michel Claude; Lounis, Nacer; US2015/87651; (2015); A1;,
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