Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19798-77-7, name is 4-Amino-3-chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Amino-3-chloropyridine
In the second step, the first step product 2- (1-butyl-1H-indol-3-yl) acetic acid was added to dichloromethane (20 mL)EDCI (1.27 g) was added at room temperature,Stirring dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.Add water (10mL) for 10min,The organic phase was added to saturated brine (10 mL) for 10 min,The organic phase was separated by column chromatography,Eluting with ethyl acetate-petroleum ether (1: 3)To give a pale yellow solidN- (3-chloropyridin-4-yl) -2- (1-butyl-1H-indol-3-yl) acetamide (1.3 g).
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Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Chen Qing; Chen Minghua; Ba Mingyu; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107151223; (2017); A;,
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