As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65189-15-3, name is 5,6-Dichloronicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H2Cl2N2
A mixture of 5,6-dichloro-nicotinonitrile (Bionet GC-0755, 500 mg, 2.89 mmol) and ethanolamine (0.87 ml_, 14.45 mmol) was prepared in anhydrous dioxane (5 ml.) and heated at 800C for 24 hours. The reaction mixture was diluted with MTBE (50 ml.) and washed with water (2×25 ml.) and brine (25 ml). The aqueous layers were extracted with MTBE (50 ml_).The organic layers were combined, dried (Na2SC>;4) and concentrated under reduced pressure to give the title compound as a white powder (510 mg, 89%). HPLC (Method A), Rt:1.9 min (purity: 99.9%). UPLC/MS, M-(ESI): 196.0.
With the rapid development of chemical substances, we look forward to future research findings about 65189-15-3.
Reference:
Patent; MERCK SERONO S.A.; QUATTROPANI, Anna; GERBER, Patrick; DORBAIS, Jerome; WO2010/100142; (2010); A1;,
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