New downstream synthetic route of 2,6-Dimethylpyridin-4-ol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13603-44-6, 2,6-Dimethylpyridin-4-ol, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13603-44-6, name is 2,6-Dimethylpyridin-4-ol, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.name: 2,6-Dimethylpyridin-4-ol

Alternative procedure: Bromine (72.8 mL, 1.4 mol) was added via addition funnel over60 mm to a mechanically stirred cold (ice-water bath) solution of 2,6-dimethylpyridin-4- ol (87 g, 706 mmol) and 4-methylmorpholine (156 mL, 1.4 mol) in dichloromethane (1 L) and methanol (100 mL) and then stirred for 2 h at rt. Additional bromine (15 mL) was added based on monitoring by LCMS. The product was filtered, washed with ether, anddried under vacuum to give 3,5-dibromo-2,6-dimethylpyridin-4-ol 176.8 g (88%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13603-44-6, 2,6-Dimethylpyridin-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; WANG, Tao; YIN, Zhiwei; (82 pag.)WO2017/6261; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem