Simple exploration of 6-Phenylpicolinaldehyde

According to the analysis of related databases, 157402-44-3, the application of this compound in the production field has become more and more popular.

Related Products of 157402-44-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 157402-44-3, name is 6-Phenylpicolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a vigorously-stirred solution of 6-phenyl-2-pyridine aldehyde (0.50 g, 2.73 mmol) in 30 ml_ of anhydrous Et2O under N2, was added a solution of benzylmagnesium chloride (3 ml_ of 1 M solution in Et2O, 3.0 mmol) at ambient temperature. After 12 h, the reaction was quenched with 5 ml_ saturated aqueous ammonium chloride. This solution was extracted with 3 x 10 ml_ EtOAc. The organic fractions were pooled, dried over Na2SO4 and concentrated. After removing the volatiles in vacuo, the resultant yellow oil was chromatographed on silica with 10% EtOAc/hexanes. Clean fractions were combined and the volatiles were removed to provide 0.31 g of the alcohol intermediate as a yellow oil (41 %).

According to the analysis of related databases, 157402-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2008/85659; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem