The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-90-3, name is 2-Chloro-4-iodonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H3ClINO
The following compounds were dissolved in a mixed solution of 200 ml of toluene, 100 ml of ethanol, and 100 ml of a 2-normal aqueous sodium carbonate solution.Compound 1-1: 3.83 g (14.3 mmol)Compound 4-4: 4.0 g (12.9 mmol)While the resulting reaction solution was stirred at a room temperature in a nitrogen atmosphere, 0.83 g (0.72 mmol) of tetrakis(triphenylphosphine)palladium(0) was added in the reacting solution. The reaction solution was heated to 60 degrees Celsius and then stuffed for 7 hours. After the reaction was completed, water was added to the reaction solution. The organic layer was extracted with toluene and dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off under reduced pressure. The residue was purified by column chromatography (gel used in chromatography: BW300 (produced by Fuji Silysia Chemical Ltd.), developing solvent:ethyl acetate/heptane = 1/2) and washed with methanol. Thus, 1.6 g (yield 38%) of Compound 4-5 was prepared.
With the rapid development of chemical substances, we look forward to future research findings about 153034-90-3.
Reference:
Patent; CANON KABUSHIKI KAISHA; ABE, Shigemoto; KAMATANI, Jun; KISHINO, Kengo; SAITOH, Akihito; YAMADA, Naoki; KOSUGE, Tetsuya; HORIUCHI, Takayuki; NISHIDE, Yosuke; MIYASHITA, Hirokazu; WO2014/115528; (2014); A1;,
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