Related Products of 117007-52-0 , The common heterocyclic compound, 117007-52-0, name is 3-Iodo-1H-pyrazolo[3,4-b]pyridine, molecular formula is C6H4IN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound (M-2) was dissolved in THF (8.4 mL)TEA (234 muL, 1.68 mmol),(Boc) 2 O (289 muL, 1.26 mmol) and DMAP(10.3 mg, 0.0839 mmol) were sequentially added,And the mixture was stirred at room temperature for 1 hour.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with water,And then washed successively with saturated brine,After drying with anhydrous sodium sulfate, filtration was carried out.After distilling off the solvent under reduced pressure,The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate)Compound (VII-10)(Yield 151 mg, Yield 52%)As a white solid.
The synthetic route of 117007-52-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; Watanabe, Atsushi; Sato, Yuki; ogura, Keiji Tamada; Tatsumi, Yoshiyuki; (283 pag.)JP2018/145180; (2018); A;,
Pyridine – Wikipedia,
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