Synthetic Route of 6975-44-6, Adding some certain compound to certain chemical reactions, such as: 6975-44-6, name is Ethyl 4,6-dihydroxynicotinate,molecular formula is C8H9NO4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6975-44-6.
A. 4,6-Dichloro-nicotinic acid ethyl ester Diethyl 1,3-acetonedicarboxylate (10 mL, 49.5 mmol) was taken in 10 mL of acetic anhydride. To the solution was added trimethylorthoformate (8.2 mL, 49.5 mmol). The mixture was heated to 120 C. for 3 hours. The reaction was then cooled and 10 mL of NH4OH (30%) was added. After stirring for additional 1 hour, the solution was triturated for 3 times in CH2Cl2 to afford 7.3 g of an off-white solid. The solid was suspended in 10 mL of POCl3 and the mixture was heated at 100 C. for 6 hours. The reaction was cooled, quenched with water, and extracted 3 times with EtOAc. The organic layer was dried over Na2SO4 and concentrated in vacuo. Flash chromatography (EtOAc/Hexanes, 1:10 v/v) afforded the title compound as a white solid (6 g, 68%). 1H NMR (400 MHz, CDCl3) delta (ppm): 8.79 (s, 1H), 7.42 (s, 1H), 4.38 (q, J=7.1 Hz, 2H), 1.37 (t, J=7.1 Hz, 3H).
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Reference:
Patent; Player, Mark R.; Huang, Hui; Hutta, Daniel A.; US2007/60577; (2007); A1;,
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