A new synthetic route of 2-Chloro-5-fluoropyridine

The synthetic route of 31301-51-6 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31301-51-6, name is 2-Chloro-5-fluoropyridine, the common compound, a new synthetic route is introduced below. Product Details of 31301-51-6

j00200J To a stirred solution of 2-chloro-5-fluoropyridine (10.0 g, 76.0 mmol, 1.0 eq.) in anhydrous THF (100 ml) was added LDA (58 mL, 116 mmol, 2M) dropwise at -78 C under N2. The mixture was kept at this temperature for 3 h, to which was added a solution of ?2 (23.2 g, 91.0 mmol) in THF (100 mL) dropwise at -78 C. The mixture was stirred for 1 h, and quenched with water (200 mL). The aqueous mixture was warmed to rt, ad extracted with EtOAc (100 mL x 2). The combined organic layers were washed with brine (50 mL x 2), dried over Na2 SO4, filtered and concentrated under vacuum. The crude product was purified by chromatography on silica gel (PE to EtOAc/PE = 1/20, v/v) to afford 2-chloro-5-fluoro-4-iodopyridine (11.8 g, 60%) as a white solid. ?H NMR (400 IVIHz, CDC13): 8.13 (s, 1H), 7.76 (d, 1H).

The synthetic route of 31301-51-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (109 pag.)WO2017/1936; (2017); A2;,
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