Adding a certain compound to certain chemical reactions, such as: 38185-56-7, 5-Bromo-3-chloro-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 38185-56-7, blongs to pyridine-derivatives compound. Recommanded Product: 38185-56-7
STEP-1 : 5 -BROMO-3 -CHLORO-2-ISOBUTOXYP YRIDINE[00214] To a solution of 5-bromo-3-chloro-2-fluoropyridine (5.0 g, 23.7 mmol, LLB Chem) and 2-methylpropan-l-ol (5.28 g, 71.3 mmol, Spectrochem) in DMSO (100 mL) was added CS2CO3(23.0 g, 71.3 mmol, GLR) and the reaction was heated at 90 C for 3 h. The reaction mixture was allowed to cool to room temperature, water (500 mL) was added and the aqueous layer was extracted with diethyl ether (2 x 500 mL). The combined organic extract was dried over sodium sulfate and concentrated under reduced pressure to obtain the crude material which was purified by column chromatography (silica gel 100-200 mesh and 0-5% ethyl acetate in hexanes) to obtain compound-3 (5.0 g, 86%) as colorless oil. TLC solvent system: 10% ethyl acetate in hexanes, product’s Rf: 0.8. MS (ESI, positive ion): No ionization.1H NMR (400 MHz, CDC13) delta 8.06 (d, J= 2.2 Hz, 1H), 7.74 (d, J= 2.2 Hz, 1H), 4.11 (d, J= 6.7 Hz, 2H), 2.12 (dp, J= 13.4, 6.7 Hz, 1H), 1.03 (d, J= 6.7 Hz, 6H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,38185-56-7, 5-Bromo-3-chloro-2-fluoropyridine, and friends who are interested can also refer to it.
Reference:
Patent; AMGEN INC.; BREGMAN, Howard; CHAKKA, Nagasree; DIMAURO, Erin F.; GAO, Hua; GUNAYDIN, Hakan; HUANG, Hongbing; OLIVIERI, Philip; SCHENKEL, Laurie; WEISS, Matthew; WO2015/51043; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem