The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1206980-39-3, name is 2-Chloro-3-(trifluoromethoxy)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Chloro-3-(trifluoromethoxy)pyridine
2-Bromo-3-trifluoromethoxypyridine (23); A solution of 2-chloro-3-trifluoromethoxypyridine (8, 4.0 g, 20.2 mmol) and bromotrimethylsilane (6.3 g, 5.4 mL, 40.4 mmol, 2 eq) in propionitrile (20 mL) was heated under reflux for 24 h. GC monitoring indicated 100% conversion. The mixture was distilled in vacuum to afford pure 2-bromo-3-trifluoromethoxypyridine (23, 3.9 g, 16.1 mmol, 80%) as a colorless oil; b.p. 63-67 0C / 13 mbar.1H NMR (CDCl3, 300 MHz): delta = 8.38 (dd, J = 4.7, 1.6 Hz, 1 H), 7.68 (d, J = 8.1, 1.6Hz, 1 H), 7.34 (dd, J = 8.1, 4.7 Hz, 1 H). – 19F NMR (CDCl3, 282 MHz): delta = -58.0. – 13C NMR (CDCl3, 75 MHz): delta = 147.8, 144.8, 142.2, 130.5, 123.7, 120.3 (q, J = 260 Hz). – C6H3ClF3NO (241): calcd. (%) C 29.78, H 1.25, N 5.79; found C 29.96, H 1.41, N 5.64.
With the rapid development of chemical substances, we look forward to future research findings about 1206980-39-3.
Reference:
Patent; BAYER CROPSCIENCE AG; PAZENOK, Sergii; VORS, Jean-Pierre; LEROUX, Frederic, R.; MANTEAU, Baptiste; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE STRASBOURG; WO2010/40461; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem