Related Products of 1122-71-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1122-71-0, name is 6-Methyl-2-pyridinemethanol, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.
A solution of 0.45 g (3.65 mmol, 1.0 eq.) of of (6-methylpyridin-2-yl)methanol in 8 mL of anhydrous acetonitrile was added to a rapidly stirred mixture of 0.89 g mmol (5.48 mmol, 1.5 eq.) of 1,1?-carbonyldiimidazole in 1.5 mL of anhydrous acetonitrile. The reaction mixture was stirred for 40 minutes, and the volatiles were then removed in vacuo. The residue was redissolved in 30 mL of ethyl acetate and washed with 30 mL of water. The layers wereseparated and the organic phase was washed with 2 x 20 mL of sat. sodium bicarbonate solution, followed by 20 mL of brine. The organic phase was dried (Na2SO4), filtered and evaporated to dryness. The residue was dried under high vacuum to provide 0.65 g (3.0 mmol, 82%) of (6-methylpyridin-2-yl)methyl imidazole-1-carboxylate (0.65g, 82% yield). ?H NMR (300 MHz, CDC13) oe: 8.20 (t, 1H), 7.65 (t, 1H), 7.50-7.45 (m, 1H), 7.23 (d, 1H), 7.17(d, 1H), 7.09 (m, 1H), 5.49 (s, 2H), 2.59 (s, 3H).
Statistics shows that 1122-71-0 is playing an increasingly important role. we look forward to future research findings about 6-Methyl-2-pyridinemethanol.
Reference:
Patent; ARBUTUS BIOPHARMA, INC.; COLE, Andrew G.; KULTGEN, Steven; (203 pag.)WO2018/52967; (2018); A1;,
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