Reference of 65156-94-7, Adding some certain compound to certain chemical reactions, such as: 65156-94-7, name is 5-Chloro-1H-pyrrolo[3,2-b]pyridine,molecular formula is C7H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65156-94-7.
A mixture of 5-chloro-lH-pyrrolo[3,2-b]pyridine (1 g, 6.55 mmol, 1 equiv), 1,1,1- trifluoro-2-iodoethane (1.4 g, 6.55 mmol, 1 equiv) and CS2CO3 (2.1 g, 6.55 mmol, 1 equiv) in 10 mL of DMF was stirred for 4 hours at 60 C. The reaction was then quenched by the addition of 30 mL of water, extracted with 10 mL of ethyl acetate and the combined organic layers concentrated under reduced pressure. The residue was purified by silica gel chromatography with ethyl acetate/petr oleum ether (1/10) to afford the desired final product as a colorless oil in 42% yield.
According to the analysis of related databases, 65156-94-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IDEAYA BIOSCIENCES, INC.; ALAM, Muzaffar; BECK, Hilary Plake; DILLON, Michael Patrick; GONZALEZ-LOPEZ, Marcos; RICO, Alice Chen; SUTTON, JR., James Clifford; (317 pag.)WO2019/18562; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem