Adding a certain compound to certain chemical reactions, such as: 58483-95-7, 5-Amino-2-chloropyridine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H5ClN2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5ClN2O2
The mixture of 5-amino-2-chloroisonicotinic acid (5.00g, 29.07mmol) and formamidine acetate (6.00g, 58.14mmol) was stirred at 160°C for 0.5h, cooled, water (100mL) was added. The mixture was refluxed under vigorous stirring for 20min, cooled again. The precipitate formed was collected, washed with water and dried to give 4.74g intermediate 15 as off-white power. Yield 90.4percent. mp>320°C. MS m/z (ESI) 182.4 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-95-7, 5-Amino-2-chloropyridine-4-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Article; Zhang, Hao; Wang, Jin; Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xin, Minhang; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3619 – 3633;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem