Related Products of 109-04-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-04-6, name is 2-Bromopyridine, molecular formula is C5H4BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1 ml (10.5 mmol) of 2-bromopyridine in 80 ml of anhydrous THF is cooled to -78 C. under a stream of argon, 9.4 ml (15 mmol) of 1.6N n-BuLi in hexane are added thereto and the mixture is stirred for 30 minutes. 3.2 ml (12 mmol) of tributyltin chloride are thus added and the mixture is stirred, still at -78 C., for 2 hours and afterwards at -20 C. for 3 hours. It is poured into an aqueous NH4Cl solution and extracted with ethyl acetate. The organic phase is dried and the solvent is evaporated. The residue is purified by chromatography on a column of silica gel, elution being carried out with a cyclohexane/ethyl acetate=9/1 mixture, 2.5 g of 2-(tributyltin)pyridine thus being obtained in the form of a yellow oil. 0.31 g of the product thus obtained is dissolved in 5 ml of toluene, and 0.13 ml (0.92 mmol) of 2-(4-bromophenyl)ethanol and 49 mg (0.042 mmol) of tetrakis(triphenylphosphine)Pd are added thereto. The mixture is heated at reflux under a stream of argon for 6 hours. The mixture is poured into water, extraction is carried out with ethyl acetate, the organic phase is dried and the solvent is evaporated. The residue is purified by chromatography on a column of silica gel, elution being carried out with a cyclohexane/ethyl acetate=1/1 and subsequently 4/6 mixture, the title product thus being obtained.
According to the analysis of related databases, 109-04-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Baroni, Marco; Bourrie, Bernard; Casellas, Pierre; Puleo, Letizia; US2005/4132; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem