With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13143-47-0, name is 1-(4-Aminophenyl)-1H-pyridin-2-one, molecular formula is C11H10N2O, molecular weight is 186.21, as common compound, the synthetic route is as follows.Quality Control of 1-(4-Aminophenyl)-1H-pyridin-2-one
Step 2: To a solution of compound 12.2 (7.44 g, 40 mmol) in 100 mL DMF was added NBS(14.2 g, 80 mmol) in small portions. The mixture was stirred at RT overnight. It was diluted with 1000 mL ethyl acetate, washed with brine three times, dried, concentrated and subjected to flash column chromatography using 5 % methanol in DCM to isolate compound 12.3 (7.20 g, 68 %). MS found for C11H9BrN2O (M+H)+ 265.0, 267.0.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13143-47-0, 1-(4-Aminophenyl)-1H-pyridin-2-one, and friends who are interested can also refer to it.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; SCARBOROUGH, Carroll; WO2008/86226; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem