Analyzing the synthesis route of 5398-44-7

Statistics shows that 5398-44-7 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloroisonicotinic acid.

Electric Literature of 5398-44-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5398-44-7, name is 2,6-Dichloroisonicotinic acid, molecular formula is C6H3Cl2NO2, molecular weight is 192, as common compound, the synthetic route is as follows.

a) A suspension of 2,6-dichloroisonicotinic acid (5.23 g, 27.24 mmol) in toluene (100 ml.) is heated to 800C and then slowly treated with N,N-dimethylformamide di-tert. butylacetal (19.94 g, 98.0 mmol). The mixture becomes slightly yellow and clear. Heating and stirring is continued for 3 h before the solution is cooled to rt, diluted with ether and washed with sat. aq. Na2CO3-solution. The org. extract is dried over MgSO4, filtered and the solvent is evaporated to give 2,6-isonicotinic acid tert.-butyl ester (6.97 g) which solidifies as beige fine needles. 1 H NMR (CDCI3): delta 1.60 (s, 6 H), 7.73 (s, 1 H).

Statistics shows that 5398-44-7 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloroisonicotinic acid.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/29371; (2008); A1;,
Pyridine – Wikipedia,
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