Adding a certain compound to certain chemical reactions, such as: 932-35-4, 3-Hydroxypicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 932-35-4, blongs to pyridine-derivatives compound. Recommanded Product: 932-35-4
[00181] To a solution of isopropyl 4-(4-chloro-leta-pyrazolo[3,4-d]pyrimidin-l- yl)piperidine- 1 -carboxylate from Example 19C (63 mg, 0.195 mmol) in 2 mL of DMF was added 3-hydroxypicolinonitrile (23.37 mg, 0.195 mmol) and potassium carbonate (53.8 mg, 0.389 mmol). The reaction was allowed to stir at room temperature for 18 h. The reaction was diluted with ethyl acetate, washed with sat’d aq sodium bicarbonate and brine, dried over MgSO4, filtered through a pad of silica gel and concentrated in vacuo to an oil. The residue was purified by silica gel chromatography (12 g ISCO cartridge, 0-90% ethyl acetate/hexane, 15 min gradient) to afford Example 19 (24 mg, 29%) as an off-white solid. 1H NMR (500 MHz, CDCl3) delta ppm 1.29 (d, J=6.05 Hz, 6 H) 2.02 – 2.08 (m, 2 H) 2.25 – 2.35 (m, 2 H) 2.98 – 3.08 (m, 2 H) 4.38 (s, 2 H) 4.94 – 5.05 (m, 2 H) 7.68 (dd, J=8.52, 4.67 Hz, 1 H) 7.88 (d, J=8.80 Hz, 1 H) 8.27 (s, 1 H) 8.49 (s, 1 H) 8.69 (d, J=4.40 Hz, 1 H). LRMS (ESI): 408.3 (M+H)+.
The synthetic route of 932-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/137436; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem