Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1227177-68-5, name is 3-Cyclopropyl-2-fluoropyridine. A new synthetic method of this compound is introduced below., Quality Control of 3-Cyclopropyl-2-fluoropyridine
STEP 3. N-(4-(3-CYCLOPROPYLPYRIDIN-2-YLOXY)PHENYL)BENZO[D]THIAZOL-2-AMINE To a solution of 4-(benzo[d]thiazol-2-ylamino)phenol (1.17 g, 4.81 mmol) in DMSO (40 mL) was added cesium carbonate (1.88 g, 5.78 mmol) and 3-cyclopropyl-2-fluoropyridine (660 mg, 4.81 mmol). The resulting mixture was heated to 125 C. for 16 h. After cooling to RT, the reaction mixture was diluted with EtOAc and washed with water and brine several times to remove DMSO. The aqueous layer was back extracted with EtOAc (3*) and the combined organic layer was dried (Na2SO4) and concentrated. The crude product was chromatographed through a Redi-Sep pre-packed silica gel column (120 g), eluding with a gradient of 0% to 30% EtOAc in hexane, to provide N-(4-(3-cyclopropylpyridin-2-yloxy)phenyl)benzo[d]thiazol-2-amine as tan solid. MS (ESI, pos. ion) m/z: 360.0 (M+1). IC50 (uM) +++++.
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Reference:
Patent; AMEN INC.; US2010/125062; (2010); A1;,
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