Extracurricular laboratory: Synthetic route of 3-Formylpyrazolo[1,5-a]pyridine-5-carbonitrile

The synthetic route of 1101120-05-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1101120-05-1, 3-Formylpyrazolo[1,5-a]pyridine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H5N3O, blongs to pyridine-derivatives compound. Formula: C9H5N3O

General procedure: A solution of the aldehyde or ketone (1 equiv) and 2-methyl-5-nitrobenzenesulfonohydrazide (1.1 equiv) in MeOH (5 mL) was refluxed for 18 h unless otherwise stated. After cooling to room temperature, the precipitated solid was filtered off, washed with a little MeOH and dried.

The synthetic route of 1101120-05-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kendall, Jackie D.; O’Connor, Patrick D.; Marshall, Andrew J.; Frederick, Raphael; Marshall, Elaine S.; Lill, Claire L.; Lee, Woo-Jeong; Kolekar, Sharada; Chao, Mindy; Malik, Alisha; Yu, Shuqiao; Chaussade, Claire; Buchanan, Christina; Rewcastle, Gordon W.; Baguley, Bruce C.; Flanagan, Jack U.; Jamieson, Stephen M.F.; Denny, William A.; Shepherd, Peter R.; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 69 – 85;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem