Adding a certain compound to certain chemical reactions, such as: 885266-91-1, 1-(2-Aminopyridin-4-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 885266-91-1, blongs to pyridine-derivatives compound. Recommanded Product: 885266-91-1
To a solution of 8-(tert-butylamino)-6-chloro-2-(2-hydroxyethyl)-2,7-naphthyridin- l(2H)-one (29.6 mg, 0.10 mmol) in 1,4-dioxane (1 mL) were added crude l-(2-aminopyridin-4-yl)ethanol (estimate 0.20 mmol), Cs2CO3 (130.3 mg, 0.40 mmol), and a catalytic amount of Pd(dba)3 and Xantphos. The reaction mixture was purged with N2 and heated at 100 C overnight. The mixture was then cooled, quenched with H2O and extracted with EtOAc. The combined organic layer was concentrated and purified by preparatory LC/MS to provide title compound; 1H NMR (CD3OD, 400 MHz) delta 8.16 (d, /= 5.6 Hz, 1H), 7.69 (s, 1H), 7.23 (d, / = 7.6 Hz, 1H), 6.97 (d, /= 5.6 Hz, 1H), 6.59 (s, 1H), 6.24 (d, / = 7.6 Hz, 1H), 4.81 (q, / = 6.4 Hz, 1H), 3.99 (t, /= 5.2 Hz, 2H), 3.81 (t, /= 5.2 Hz, 2H), 1.57 (s, 9H), 1.45 (d, / = 6.4 Hz, 3H); ESI-MS ml z 398.2 (MH+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,885266-91-1, 1-(2-Aminopyridin-4-yl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; IRM LLC; CHE, Jianwei; CHEN, Bei; DING, Qiang; HAO, Xueshi; HE, Xiaohui; JIANG, Songchun; JIN, Qihui; JIN, Yunho; LIU, Hong; LIU, Yahua; OKRAM, Barun; UNO, Tetsuo; WU, Xu; YANG, Kunyong; ZHU, Xuefeng; WO2011/14515; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem