Application of 5912-18-5 , The common heterocyclic compound, 5912-18-5, name is 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4,6-dichloro-1H-pyrrolo[2,3-b]pyridine (1.0 eq) was dissolved in DMF and the temperature was lowered to minus 10 C.To the mixture was added N-iodosuccinimide (1.1 equivalent), the temperature was raised to room temperature, and stirred for 1 hour. After the reaction, ice water was added to induce precipitation. The formed precipitate was filtered to give the desired compound as white. (Yield: 100%).
The synthetic route of 5912-18-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dae Caliber Buk Peak Medical Industry Promotion Foundation; Korea Research Institute of Bioscience and Biotechnology; Daegu Gyeongbuk Institute of Science & Technology; Choi Hwan-geun; Go Eun-hwa; Cho Jung-hui; Son Jeong-beom; Go I-gyeong; Park Jin-hui; Kim So-yeong; Kang Seok-yong; Lee Seung-yeon; Ryu Hui-yun; Kim Nam-du; Kim Sang-beom; Lee Seon-hwa; Kim Da-ye; Lee Seon-ju; Cho Seong-chan; Lee Gyu-seon; Ryu Gwon; Choi Mi-ri; Gu Ja-uk; Huh Hyang-suk; (84 pag.)KR101896568; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem