As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 787596-41-2, name is Methyl 2-chloro-3-methylisonicotinate, molecular formula is C8H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 787596-41-2
To a solution of methyl 2-chloro-3-methylisonicotinate (6.00 g, 32.32 mmol) in CC14 (30 mL) was added NBS (6.06 g, 33.94 mmol) and BPO (780 mg, 3.23 mmol). After addition, the reaction mixture was heated to reflux for 3 h. TLC indicated that starting material was consumed. Then, it was cooled to ambient temperature and the resulting precipitate wasremoved by filtration, washed by CC14 (5 mL). The filtrate was concentrated in vacuo to give the crude product methyl 3-(bromomethyl)-2-chloroisonicotinate as a yellow oil, which was used in next step without further purification.
With the rapid development of chemical substances, we look forward to future research findings about 787596-41-2.
Reference:
Patent; SHANGHAI METON PHARMACEUTICAL CO., LTD; YANG, Jibin; (102 pag.)WO2018/10142; (2018); A1;,
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