A new synthetic route of 7418-65-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7418-65-7, 4-Aminonicotinic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 7418-65-7, Adding some certain compound to certain chemical reactions, such as: 7418-65-7, name is 4-Aminonicotinic acid,molecular formula is C6H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7418-65-7.

(E)-[6-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]]-3-pyhdinecarboxylic acid (FT104)A suspension of (£)-3-(3,4-dimethoxyphenyl)-2-propenoic acid (1.0 g, 4.8 mmol) in CH2CI2 (10 mL) was treated with oxalyl chloride (1.6 ml_, 19 mmol). The solution was stirred at rt for 1 h and the solvent was removed under reduced pressure to give the acid chloride as a yellow solid. 4-Aminonicotinic acid (0.73 g, 5.3 mmol) was added to a solution of the acid chloride (4.8 mmol) in pyridine (5.0 mL) and the suspension was heated to reflux and stirred for 5 d. The solution was diluted with water and the precipitate was collected by filtration providing (£)-[6-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2- propenyl]amino]]-3-pyridinecarboxylic acid (0.25 g, 16%) as a colourless solid; mp 258- 260 0C; deltaH (500 MHz, DMSO-d6) 3.80 (s, 3H, OCH3), 3.83 (s, 3H, OCH3), 6.82 (d, J = 15.5 Hz, 1H1 CH=CHCO), 7.00 (d, J5.ibeta. = 8.0 Hz, 1 H, H5′), 7.23 (dd, J6.>beta. = 8.0, J2,6. = 2.0 Hz, 1 H1 H6′), 7.33 (s, J2, 6. = 2.0 Hz, 1H, H2′), 7.62 (d, J = 15.5 Hz, 1H, CH=CHCO), 8.60 (d, J5,6 = 8.0 Hz, 1 H, H5), 8.63 (d, J5j6 = 8.0 Hz, 1H, H6), 9.03 (s, 1H, H2); HRMS (ESI) calculated for C17H14N2O4 [M+H]+ 329.1132, found 329.1129; vmax 1140, 1262, 1488, 1623, 2938, 3543 cm”1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7418-65-7, 4-Aminonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FIBROTECH THERAPEUTICS PTY LTD; WILLIAMS, Spencer John; ZAMMIT, Steven; KELLY, Darren James; JAMES, Ian William; WO2010/144959; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem