Synthetic Route of 149806-06-4 ,Some common heterocyclic compound, 149806-06-4, molecular formula is C6H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Reagents: i) Methaneboronic acid, 16%; ii) Ethyl acrylate ; iii) NaOH, 35% yield for the last two steps.LC/MS data of 2805 – Calculated MW is 177; observed (the peak at 11.2 min, TIC): 178 [M+H].Gradient: 0-5 min: 5% ACN; 5-20 min: 5-10% ACN; 20-30 min: 10-98%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,149806-06-4, its application will become more common.
Reference:
Patent; TRUSTEES OF TUFTS COLLEGE; WO2008/16968; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem